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  1. T.-K. Chang,# Y.-Y. Tseng,# M.-J. Lee,* and W. Lee.* 2023. Optical and flexoelectric biosensing based on a hybrid-aligned liquid crystal of anomalously small bend elastic constant. Biosens. Bioelectron. 232: 115314 (*corresponding author; SCIE, 3/87, Chemistry, Analytical, 2021 IF 12.545).

  2. T.-K. Chang, M.-J. Lee,* and W. Lee.* 2023. Signal amplification strategies for optical biodetection at the liquid crystal–solid interface. Liq. Cryst. Accepted (*corresponding author; SCIE, 11/26, crystallography, 2021 IF 2.676).

  3. H. Shaban, J.-T. Hsieh, M.-J. Lee,* and W. Lee.* 2023. Label-free optical and electrical immunoassays based on lyotropic chromonic liquid crystals: Implications of real-time detection and kinetic analysis. Biosens. Bioelectron. 223: 115011 (*corresponding author; SCIE, 3/87, Chemistry, Analytical, 2021 IF 12.545).

  4. W.-C. Kao, J.-C. Chen, P.-C. Liu, C.-C. Lu, S.-Y. Lin, S.-C. Chuang, S.-C. Wu, L.-h. Chang, M.-J. Lee, C.-D. Yang, T.-C. Lee, Y.-C. Wang, J.-Y. Li, C.-W. Wei, C.-H. Chen. 2022. The role of autophagy in osteoarthritic cartilage. Biomolecules 12: 1357 (SCIE, 75/297, Biochemistry & Molecular Biology, 2021 IF 6.064).

  5. T.-K. Chang, P.-C. Tung, M.-J. Lee,* and W. Lee.* 2022. A liquid-crystal aptasensing platform for label-free detection of a single circulating tumor cell. Biosens. Bioelectron. 216: 114607 (*corresponding author; SCIE, 3/87, Chemistry, Analytical, 2021 IF 12.545).

  6. B.-S. Chen, M.-J. Lee,* and W. Lee.* 2022. Multimodal spectrometric and dielectric biosensing with an ionic-surfactant-doped liquid crystal. Sens. Actuator B-Chem. 365: 131912 (*corresponding author; SCIE, 2/64, Instruments & Instrumentation, 2021 IF 9.221).

  7. H.-Y. Liu, C.-F. Chang, C.-C. Lu, S.-C. Wu, B. Huang, T.-L. Cheng, S.-Y. Lin, C.-J. Ho, M.-J. Lee, C.-D. Yang, Y.-C. Wang, J.-Y. Li, P.-C. Liu, C.-W. Wei, L. Kang, C.-H. Chen. 2022. The role of mitochondrial metabolism, AMPK-SIRT mediated pathway, LncRNA and MicroRNA in osteoarthritis. Biomedicines 10: 1477 (SCIE, 87/279, Pharmacology & Pharmacy, 2021 IF 4.757).

  8. T.-K. Chang, M.-J. Lee,* and W. Lee.* 2022. Quantitative biosensing based on a liquid crystal marginally aligned by the PVA/DMOAP composite for optical signal amplification. Biosensors 12: 218 (*corresponding author; SCIE, 8/64, Instruments & Instrumentation, 2021 IF 5.743).

  9. Y.-Q. Wang, P.-C. Wu, M.-J. Lee,* and W. Lee.* 2022. Photocontrolled capacitive biosensor based on photoresponsive azobenzene-doped liquid crystals for label-free protein assay. J. Mol. Liq. 345: 117908 (*corresponding author; SCIE, 6/36, Physics, Atomic, Molecular & Chemical, 2021 IF 6.633).

  10. C.-H. Cheng, M.-Y. Shie, Y.-H. Lai, N.-P. Foo, M.-J. Lee,* and C.-H. Yao.* 2021. Fabrication of 3D printed poly (lactic acid)/polycaprolactone scaffolds using TGF-β1 for promoting bone regeneration. Polymers 13: 3731 (*corresponding author; SCIE, 16/90, Polymer Science, 2021 IF 4.967).

  11. P.-C. Wu, C.-P. Pai, M.-J. Lee,* and W. Lee.* 2021. A single-substrate biosensor with spin-coated liquid crystal film for simple, sensitive and label-free protein detection. Biosensors 11: 374 (*corresponding author; SCIE, 8/64, Instruments & Instrumentation, 2021 IF 5.743).

  12. H. Shaban, M.-J. Lee,* and W. Lee.* 2021. Label-free detection and spectrometrically quantitative analysis of the cancer biomarker CA125 based on lyotropic chromonic liquid crystal. Biosensors 11: 271 (*corresponding author; SCIE, 8/64, Instruments & Instrumentation, 2021 IF 5.743).

  13. C.-C. Lee,# C.-M. Hung,# C.-H. Chen, Y.-C. Hsu, Y.-P. Huang, T.-B. Huang, and M.-J. Lee.* 2021. Novel aptamer-based small-molecule drug screening assay to identify potential sclerostin inhibitors against osteoporosis. Int. J. Mol. Sci. 22: 8320 (#The authors contributed equally to this work; *corresponding author; SCIE, 69/297, Biochemistry & Molecular Biology, 2021 IF 6.208).

  14. M.-J. Lee,** C.-P. Pai, P.-C. Wu, and W. Lee.* 2021. Label-free single-substrate quantitative protein assay based on optical characteristics of cholesteric liquid crystals. J. Mol. Liq. 331: 115756 (**first and corresponding author; SCIE, 6/36, Physics, Atomic, Molecular & Chemical, 2021 IF 6.633).

  15. R. B. Barndt, M.-J. Lee, N. Huang, D. D. Lu, S.-C. Lee, P.-W. Du, C.-C. Chang, P.-F. B. Tsai, Y.-S. K. Huang, H.-M. Chang, J.-K. Wang, C.-H. Lai,* M. D. Johnson,* C.-Y. Lin.* 2021. Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells. Hum. Mol. Genet. 30: 1833–1850 (SCIE, 36/175, Genetics & Heredity, 2021 IF 5.121; International collaboration).

  16. H. Shaban, S.-C. Yen, M.-J. Lee,* and W. Lee.* 2021. Signal amplification in an optical and dielectric biosensor employing liquid crystal-photopolymer composite as the sensing medium. Biosensors 11: 81 (*corresponding author; SCIE, 8/64, Instruments & Instrumentation, 2021 IF 5.743).

  17. C.-D. Yang, S.-C. Chuang, T.-L. Cheng, M.-J. Lee, H.-T. Chen, S.-Y. Lin, H.-T. Huang, C.-J. Ho, Y.-S. Lin, L. Kang, M.-L. Ho, J.-K. Chang,* C.-H. Chen.* 2021. An intermediate concentration of calcium with antioxidant supplement in culture medium enhances proliferation and decreases the aging of bone marrow mesenchymal stem cells. Int. J. Mol. Sci. 22: 2095 (SCIE, 69/297, Biochemistry & Molecular Biology, 2021 IF 6.208).

  18. L. B. B. Aquino, M. Y. U. Barbaza, J. L. T. Ramos, M.-J. Lee, S.-Y. Ko, C.-L. Hsieh, K. A. De Castro-Cruz,* and P.-W. Tsai.* 2020. Aerial parts of Euphorbia hirta L. in polar and non-polar solvents: phytochemical, antioxidant and glucose uptake studies for potential source of adjunct drug for diabetes. Trop. J. Nat. Prod. Res. 4: 708–713 (Scopus, SJR 2021 0.13, Q4 in Analytical Chemistry; International collaboration).

  19. B. Jia, H. A. Thompson, R. B. Barndt, Y.-L. Chiu, M.-J. Lee, S.-C. Lee, J.-K. Wang, H.-J. Tang,* C.-Y. Lin,* and M. D. Johnson.* 2020. Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation. Hum. Cell. 33: 1068–1080 (SCIE, 107/195, Cell Biology, 2021 IF 4.374; International collaboration).

  20. M.-J. Lee,** F.-F. Duan, P.-C. Wu, and W. Lee.* 2020. Liquid crystal‒photopolymer composite films for label-free single-substrate protein quantitation and immunoassay. Biomed. Opt. Express 11: 4915–4927 (**first and corresponding author; SCIE, 31/101, Optics, 2021 IF 3.562).

  21. M.-J. Lee** and W. Lee.* 2020. Liquid crystal-based capacitive, electro-optical and dielectric biosensors for protein quantitation. Liq. Cryst. 47: 1145–1153 (**first and corresponding author; SCIE, 11/26, crystallography, 2021 IF 2.676).

  22. W.-L. Hsu, M.-J. Lee,* and W. Lee.* 2019. Electric-field-assisted signal amplification for label-free liquid-crystal-based detection of biomolecules. Biomed. Opt. Express 10: 4987–4998 (*corresponding author; SCIE, 31/101, Optics, 2021 IF 3.562).

  23. C.-M. Lin, P.-C. Wu,M.-J. Lee,* and W. Lee.* 2019. Label-free protein quantitation by dielectric spectroscopy of dual-frequency liquid crystal. Sens. Actuator B-Chem. 282: 158–163 (*corresponding author; SCIE, 2/64, Instruments & Instrumentation, 2021 IF 9.221).

  24. S. Y. Lin, L. Kang, J. C. Chen, C. Z. Wang, H. H. Huang, M.-J. Lee, T. L. Cheng, C. F. Chang, Y. S. Lin, and C. H. Chen.* 2019. (−)-Epigallocatechin-3-gallate (EGCG) enhances healing of femoral bone defect. Phytomedicine, 55: 165–171 (SCIE, 1/30, Integrative & Complementary Medicine, 2021 IF 6.656).

  25. S. Y. Lin, L. Kang, C. Z. Wang, H. H. Huang, T. L. Cheng, H. T. Huang, M.-J. Lee, Y. S. Lin, M. L. Ho, G. J. Wang, and C. H. Chen.* 2018. (−)-Epigallocatechin-3-gallate (EGCG) enhances osteogenic differentiation of human bone marrow mesenchymal stem cells. Molecules, 23: 3221 (SCIE, 65/179, Chemistry, Multidisciplinary, 2021 IF 4.927).

  26. M.-J. Lee,** Y.-L. Chiang, A. Karn, P.-C. Wu, and W. Lee.* 2018. Dye- and dye-doped liquid crystals in biosensing. Proc. SPIE 10735, Liquid Crystals XXII, 1073509 (14 September 2018); doi: 10.1117/12.2319014 (**first and corresponding author; EI).

  27. Y.-L. Chiang, M.-J. Lee,* and W. Lee.* 2018. Enhancing detection sensitivity in quantitative protein detection based on dye-doped liquid crystals. Dyes Pigment. 157: 117–122 (*corresponding author; SCIE, 3/26, Materials Science, Textiles, 2021 IF 5.122).

  28. P.-C. Wu, A. Karn, M.-J. Lee,* W. Lee,* and C.-Y. Chen. 2018. Dye-liquid-crystal-based biosensing for quantitative protein assay. Dyes Pigment. 150: 73–78 (*corresponding author; SCIE, 3/26, Materials Science, Textiles, 2021 IF 5.122).

International Conference

  1. M.-J. Lee.* Diversity and versatility of liquid crystals as the transducing medium for next-generation biosensing technologies. International Conference on Smart Sensors 2023 (ICSS2023), National Cheng Kung University, Tainan, Taiwan, June 19–20, 2023. [Keynote presentation]

  2. M.-J. Lee,* H. Shaban, and W. Lee*, “Nematic Lyotropic Chromonic Liquid Crystals as Smart Biosensing Materials,” oral presentation, contributed paper 0044, abstract available to registered conference attendees, International Conference on Smart Sensors 2022 (ICSS2022), National Chung Hsing University, Taichung, Taiwan, October 22–23, 2022.

  3. Y.-Y. Tseng, T.-J. Chang, P.-C. Wu, M.-J. Lee, and W. Lee*, “Biosensing with a hybrid-alignment cell of nematic mixed with a bimesogenic liquid crystal dimer,” oral presentation, invited paper I10, abstract in Abstract Book OLC2021 SWS2022, Satellite Workshop of the 19th Optics of Liquid Crystals (OLC 2021), Bankoku Shinryo-kan at Busena, Okinawa, Japan, September 25–30, 2022.

  4. M.-J. Lee* and W. Lee. Liquid crystal-based single-substrate biosensors as next-generation point-of-care testing devices, oral presentation, contributed paper FO-36, 28th International Liquid Crystal Conference (ILCC 2022), NOVA School of Science and Technology, Lisbon, Portugal, July 24–29, 2022.

  5. H. Shaban, M.-J. Lee,* and W. Lee*. Label-free bioassay based on a nematic aqueous solution of a food coloring dye, online oral presentation, contributed paper FO-34, 28th International Liquid Crystal Conference (ILCC 2022), NOVA School of Science and Technology, Lisbon, Portugal, July 24–29, 2022.

  6. W. Lee* and M.-J. Lee. Liquid crystal cells for biosensing: texture observation and beyond, oral presentation, keynote paper ILK-4-AIV, 28th International Liquid Crystal Conference (ILCC 2022), NOVA School of Science and Technology, Lisbon, Portugal, July 24–29, 2022.

  7. P.-C. Wu, C.-P. Pai, F.-F. Duan, M.-J. Lee,* and W. Lee.* Liquid crystal film on a single substrate for biosensing. 19th Optics of Liquid Crystals Conference (OLC 2021), Okinawa, Japan, September 26–October 1, 2021.

  8. H. Shaban, M.-J. Lee,* and W. Lee.* Label-free bioassay based on lyotropic chromonic liquid crystal. SPIE Optics + Photonics 2021, August 1–5, 2021.

  9. M.-J. Lee,* C.-P. Pai, P.-C. Wu, and Wei Lee.* Photonic liquid crystals on a single substrate for label-free protein assays. SPIE Optics + Photonics 2021, August 1–5, 2021.

  10. H. Shaban, M.-J. Lee,* and W. Lee.* Optical detection of bovine serum albumin by lyotropic liquid crystal. 2020 OSA Frontiers in Optics + Laser Science APS/DLS Conference (FiO+LS), Technical Conference & Virtual Exhibits, September 14–17, 2020.

  11. S.-C. Yen, P.-C. Wu, M.-J. Lee,* and W. Lee.* Enhancement of the limit of protein detection based on polymer-stabilized liquid crystals. Optics & Photonics Taiwan, International Conference 2019 (OPTIC 2019), Taichung, Taiwan, December 5–7, 2019.

  12. W.-L. Hsu, M.-J. Lee,* and W. Lee.* Signal Amplification for biodetection in field-assisted optical sensing. Optics & Photonics Taiwan, International Conference 2019 (OPTIC 2019), Taichung, Taiwan, December 5–7, 2019.

  13. W.-L. Hsu, M.-J. Lee,* and W. Lee.* Electric field-assisted signal amplification for liquid crystal-based protein detection. 18th Optics of Liquid Crystals Conference (OLC 2019), Québec, Canada, September 8–13, 2019.

  14. M.-J. Lee* and W. Lee.* Exploiting the electrical and optical properties of liquid crystals in biosensing and quantitative bioassays. The 14th Asian Congress on Biotechnology (ACB2019), Taipei, Taiwan, July 1‒4, 2019.

  15. F.-F. Duan, P.-C. Wu, M.-J. Lee,* and W. Lee.* Immunoassay of the cancer biomarker CA125 using a liquid-crystal-coated substrate. 4th Asian Conference on Liquid Crystals (ACLC 2019), Shenzhen, China, January 17–18, 2019.

  16. W.-L. Hsu, P.-C. Wu, M.-J. Lee,* and W. Lee.* DNA biosensing based on an unsandwiched liquid crystal. 4th Asian Conference on Liquid Crystals (ACLC 2019), Shenzhen, China, January 17–18, 2019.

  17. W.-L. Hsu, C.-P. Pai, P.-C. Wu, M.-J. Lee,* and W. Lee.* Label-free biodetection based on a liquid crystal film coated on a single substrate. Optics & Photonics Taiwan, International Conference 2018 (OPTIC 2018), Tainan, Taiwan, December 6–8, 2018.

  18. C.-M. Lin, P.-C. Wu, W.-K. Wu, M.-J. Lee,* and W. Lee.* Dielectric spectroscopy-based label-free protein quantitation using dual-frequency liquid crystal. Optics & Photonics Taiwan, International Conference 2018 (OPTIC 2018), Tainan, Taiwan, December 6–8, 2018.

  19. W.-L. Hsu, C.-P. Pai, P.-C. Wu, M.-J. Lee,* and W. Lee.* Biomolecule detection based on a liquid crystal film coated on a single substrate. 2018 OSA Frontiers in Optics + Laser Science APS/DLS Conference (FiO+LS), Washington, DC, USA, September 17–20, 2018.

  20. M.-J. Lee and W. Lee.* Optical, capacitance and dielectric methods for liquid-crystal-based biosensing. Oral presentation, plenary lecture, 22nd International Symposium on Advanced Display Materials and Devices (ADMD 2018), Jeju, South Korea, July 10–13, 2018.

  21. Y.-L. Chiang, M.-J. Lee,* and W. Lee.* High-sensitivity biosensing for protein detection using dye-doped liquid crystals and polarized light. 28th Anniversary World Congress on Biosensors (Biosensors 2018), Miami, FL, USA, June 12–15, 2018.

  22. C.-M. Lin, P.-C. Wu, M.-J. Lee,* and W. Lee.* Label-free protein quantitation by means of dielectric spectroscopy with dual-frequency liquid crystal. 28th Anniversary World Congress on Biosensors (Biosensors 2018), Miami, FL, USA, June 12–15, 2018.

  23. M.-J. Lee, H.-W. Su, S.-H. Sun, A. Karn, Y.-C. Hsiao, C.-H. Chang, C.-H. Lin, C.-M. Lin, P.-C. Wu, and Wei Lee.* Optical, capacitance and dielectric methods for liquid-crystal-based biosensing. The 7th international symposium on liquid crystal photonics (SLCP 2018), Changshu, Jiangsu, China, April 13–15, 2018.

  24. M.-J. Lee,* Y. P. Huang, and C. C. Chen. Potential bone-stimulating sclerostin inhibitors screened from an aptamer-based competitive assay. 10th World Congress and Expo on Cell & Stem Cell Research, New York, USA, March 19–21, 2018.

Domestic Conference

  1. T.-K. Chang, M.-J. Lee*, and W. Lee*, “Liquid-crystal aptadetection of a single circulating tumor cell,” poster presentation, contributed paper PT-23, abstract in Program of the 2022 Annual Meeting of Taiwan Liquid Crystal Society, p. 40; paper in Proceedings of the 2022 Annual Meeting of TLCS on Internet, pp. 202–205, Mabu Ville, Hsinchu, Taiwan, November 25, 2022.

  2. H. Shaban, J.-T. Hsieh, M.-J. Lee*, and W. Lee**, “Real-time detection and kinetic analysis in immunoassay with lyotropic liquid crystals,” poster presentation, contributed paper PT-16, abstract in Program of the 2022 Annual Meeting of Taiwan Liquid Crystal Society, p. 36; paper in Proceedings of the 2022 Annual Meeting of TLCS on Internet, pp. 178–182, MaBu Ville, Hsinchu, Taiwan, November 25, 2022

  3. Y.-Y. Tseng, T.-C. Tsai, M.-J. Lee*, and W. Lee**, “Flexoelectric biosensing based on a hybrid-aligned chiral nematic of anomalously small bend elastic constant,” poster presentation, contributed paper PT-18, abstract in Program of the 2022 Annual Meeting of Taiwan Liquid Crystal Society, p. 37; paper in Proceedings of the 2022 Annual Meeting of TLCS on Internet, pp. 187–189, MaBu Ville, Hsinchu, Taiwan, November 25, 2022.

  4. M.-J. Lee. Biosensing applications of liquid crystals: Interfacing with biological analytes. 2021 Annual Meeting of Taiwan Liquid Crystal Society, Taiwan, December 17, 2021. [Keynote presentation]

  5. H. Shaban, M.-J. Lee,* and W. Lee.* Spectrometric measurement of optical signal for label-free and lyotropic-liquid-crystal-based biosensing. 2020 Annual Meeting of Taiwan Liquid Crystal Society, Tainan, Taiwan, December 18, 2020.

  6. Y.-Q. Wang, P.-C. Wu, M.-J. Lee,* and W. Lee.* Label-free biosensing by using photo-responsive azo-chiral-doped-liquid-crystal. 2020 Annual Meeting of Taiwan Liquid Crystal Society, Tainan, Taiwan, December 18, 2020.

  7. B.-S. Chen, P.-C. Wu, M.-J. Lee,* and W. Lee.* Characteristics of a label-free biosensor by using cationic surfactant-doped liquid crystal. 2020 Annual Meeting of Taiwan Liquid Crystal Society, Tainan, Taiwan, December 18, 2020.

  8. S.-C. Yen, Y.-Y. Tseng, M.-J. Lee,* and W. Lee.* Nematic–polymer integrated cell platforms for biosensing. 2020 Annual Meeting of Taiwan Liquid Crystal Society, Tainan, Taiwan, December 18, 2020.

  9. W.-L. Hsu, H. Shaban, M.-J. Lee,* and W. Lee.* Electrically enhanced optical signal for label-free and liquid-crystal-based biosensing. 2019 Annual Meeting of Taiwan Liquid Crystal Society, Hsinchu, Taiwan, December 20, 2019. [TLCS Outstanding Poster Award]

  10. Y.-L. Chiang, S.-C. Yen, M.-J. Lee,* and W. Lee.* Enhancement of detection sensitivity in quantitative protein assay based on dye-doped liquid crystal. 2018 Annual Meeting of Taiwan Liquid Crystal Society, Taipei, Taiwan, December 21, 2018.

  11. C.-M. Lin, W.-G. Wu, P.-C. Wu, M.-J. Lee,* and W. Lee.* Dielectric biosensor for label-free protein detection with dual-frequency liquid crystal. 2018 Annual Meeting of Taiwan Liquid Crystal Society, Taipei, Taiwan, December 21, 2018.

  12. F.-F. Duan, P.-C. Wu, M.-J. Lee,* and W. Lee.* Detection of the cancer biomarker CA125 probed by a nematic film on a single glass substrate. 2018 Annual Meeting of Taiwan Liquid Crystal Society, Taipei, Taiwan, December 21, 2018.

  13. W.-L. Hsu, P.-C. Wu, M.-J. Lee,* and W. Lee.* Unsandwiched liquid crystal for bioassay of proteins and DNA. 2018 Annual Meeting of Taiwan Liquid Crystal Society, Taipei, Taiwan, December 21, 2018.

Book Chapter

​M.-J. Lee and W. Lee. 2021. Liquid crystal-based biosensing: exploiting the electrical and optical properties of various liquid crystals in quantitative bioassays, in: Lee, W., Kumar, S. (Eds.), Unconventional Liquid Crystals and Their Applications, De Gruyter, Berlin, pp. 239‒264. https://doi.org/10.1515/9783110584370-005

Patent

李偉、李孟娟、孫士弘、蘇慧汶。液晶感測器及用於檢測生物分子的方法。中華民國專利，發明第I 491877 號，專利權期間2015年7月11日至2034年6月18日。

Journal Papers

PUBLICATIONS (2018 TO DATE)

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